Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products

The synthesis of natural products 2-(2,3-dibromo-4,5-dihydroxyphenyl)acetic acid (1) and 2-(2,6-dibromo-3,5-dihydroxyphenyl)acetic (2) as well their derivatives 25 26 were carried out by substitution, hydrolysis demethylation reactions the corresponding four benzyl bromides. antioxidant potentials benzylic acid-derived bromophenols were, for first time, appraised several outstanding bioanalytical methods. Besides these, we estimated effects which studied using methods DPPH·, ABTS·+ scavenging activities, ferric (Fe3+) cupric (Cu2+) ions Fe3+-TPTZ reducing capacities. Benzylic found effective scavengers. potential activities bromophenol 1, 2 17-28 compared to standard antioxidants including BHA, BHT, ?-Tocopherol, Trolox, is a water-soluble analog vitamin E. We expect that this innovative work will direct future studies exploring properties food, medicinal, industrial applications.